2025 NFL Week 4 Picks: Simms vs. Florio - NBC Sports (2025)

This week's NFL picks could be the closest battle of the season yet—just one game separates Florio and Simms in their rivalry. With only one matchup left to decide the winner, the stakes have never been higher. Let’s break down what’s at stake and why this week’s matchups might be the most pivotal of the year.

But here's where it gets controversial: Simms has been riding a wave of momentum, winning 12-4 in the microcontest last week, while Florio holds a 36-12 overall record. Yet, despite their differences, they’ve only clashed on one game this season. That’s a rare moment of agreement in a world of constant disagreement.

For those new to betting, remember: the numbers don’t always tell the full story. A 26-22 edge in straight-up wins for Florio contrasts sharply with Simms’ 19-29 against the spread. It’s not just about the stats—it’s about understanding the nuances of each game. For instance, the Seahawks vs. Cardinals matchup shows both teams exceeding expectations, but the Seahawks’ slight edge makes the 23-20 pick a logical choice.

And this is the part most people miss: the spread on the Commanders vs. Falcons game is unusually small. Why? Because Dan Quinn’s defensive adjustments have been so effective that even a 1.5-point gap feels like a major hurdle. Florio leans into the Commanders’ strength, predicting a 30-17 victory, while Simms favors a tighter score.

Let’s not forget the underdog stories. The Bills vs. Saints game is a classic case of a team fighting to survive. Florio believes the Bills can pull off a 24-14 upset, but Simms thinks the Saints will dominate with a 34-17 scoreline. Which scenario feels more plausible?

As the season progresses, the pressure mounts. In the Chargers vs. Giants game, a loss for the Patriots could derail their playoff hopes. Florio sees the Chargers as the underdog, while Simms trusts the Giants’ resilience. This is where the debate really starts.

Ultimately, the real test comes down to which analyst can predict the most unpredictable games. Florio’s 36-12 record suggests a strategic mind, while Simms’ 29-19 track record hints at a different approach. What do you think will happen in the Dolphins vs. Jets game? Share your thoughts in the comments—because in sports, the best bets are the ones we’re most confident about.

2025 NFL Week 4 Picks: Simms vs. Florio - NBC Sports
 (2025)
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